In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids

In-silico Leishmania target selectivity of antiparasitic terpenoids.

Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by the parasites to the few available drugs. Many antiparasitic plant-derived isoprenoids have been reported, and many of them have good in vitro...

In silico analysis of a therapeutic target in Leishmania infantum: the guanosine-diphospho-D-mannose pyrophosphorylase

Leishmaniases are tropical and sub-tropical diseases for which classical drugs (i.e. antimonials) exhibit toxicity and drug resistance. Such a situation requires to find new chemical series with antileishmanial activity. This work consists in analyzing the structure of a validated target in Leishmania: the GDP-mannose pyrophosphorylase (GDP-MP), an enzyme involved in glycosylation and essential...

Target assessment for antiparasitic drug discovery.

Drug discovery is a high-risk, expensive and lengthy process taking at least 12 years and costing upwards of US$500 million per drug to reach the clinic. For neglected diseases, the drug discovery process is driven by medical need and guided by pre-defined target product profiles. Assessment and prioritisation of the most promising targets for entry into screening programmes is crucial for maxi...

Potential of Terpenoids and Flavonoids from Asteraceae as Anti-Inflammatory, Antitumor, and Antiparasitic Agents

1Departamento de Farmacologı́a, Cátedra de Farmacognosia, Facultad de Farmacia y Bioquı́mica, Universidad de Buenos Aires, Buenos Aires, Argentina 2Universidad de Buenos Aires, CONICET, Instituto de Quı́mica y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina 3Instituto de Fisiologı́a Animal, Fundación Miguel Lillo y Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nac...

In Silico Investigation of Off-Target Effects